Grants

The Role of Complex Translocations Associated with TP53 Somatic Mutations for Aiding Prognosis of Canine Diffuse Large B cell Lymphoma When Treated with Standard of Care CHOP Chemotherapy

Lymphoma accounts for up to 24% of all cancers diagnosed in pet dogs. Among these cases diffuse large B-cell lymphoma (DLBCL) is the most common subtype. Despite continued advances in veterinary medicine, the response to treatment for canine lymphoma remains highly variable with no reliable means to predict response. 

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Targeting the Cancer Epigenome: The Effect of Specific Histone Lysine Methyltransferase Inhibition in Canine B-Cell Lymphoma

Canine lymphoma is one of the most common cancers in dogs. While some breeds appear more at risk than others, all can be affected. While often treatable, canine lymphoma can rarely be cured. A continued understanding of the mechanisms causing lymphoma in dogs and identification of novel therapies are needed to improve survival in dogs with lymphoma. 

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The Microbiota-Gut-Brain Axis in Canine Epilepsy: Determining the Role of Lactobacilli

Epilepsy is the most common nervous system disorder of dogs, affecting up to 0.75% of the canine population. Approximately one-third of dogs with epilepsy fail to achieve adequate seizure control with anti-seizure medication. This study aims to evaluate the role of certain intestinal bacteria in the management of epilepsy in dogs. Alterations

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The Identification of Genetic Risk Factors for Canine Epilepsy

Epilepsy is one of the most common neurologic diseases of dogs and a top concern of dog breeders. Despite strong evidence that genetics is important in determining the risk of idiopathic epilepsy, numerous gene mapping studies have failed to identify a locus that accounts for that risk in either dogs or humans. Seizures occur when

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Efficacy of Cannabidiol (CBD) for the Treatment of Canine Epilepsy

Epilepsy is the most common neurologic condition in dogs. Approximately 20-30% of dogs receiving standard therapy remain uncontrolled for their seizures. Additionally, the side effects of the antiepileptic drugs (AED) are often unacceptable. Thus, there is a need for an AED that is efficacious with minimal side effects. Cannabidiol

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Harnessing a Dog’s Own Immune System to Kill Lymphoma Tumor Cells

Lymphoma is the most common malignancy of dogs representing up to 25% of diagnosed cancers. Dogs often develop an aggressive form of lymphoma that is rarely curable, with most unfortunately succumbing to disease within 12 months of diagnosis despite best-available chemotherapies. Dr. Wilson will develop a new treatment to re-train the dog’s own immune system to attack the most common type of canine lymphoma, B-cell lymphoma.

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Disease Risks Associated with Spay and Neuter: A Breed-Specific, Gender-Specific Perspective

This project extends the investigator’s recently completed AKC Canine Health Foundation grant (01840) studying 12 breeds to identify major differences in the degree to which spay or neuter may be related to an increase in joint disorders (hip dysplasia; cranial cruciate ligament tear) and/or cancers (lymphoma; hemangiosarcoma; and mast cell tumor). The original breeds studied were: Labrador Retriever, Golden Retriever, German Shepherd Dog, 

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Lyme Disease in Dogs: Prevalence, Clinical Illness, and Prognosis

Lyme disease (or Borreliosis) is a bacterial disease of dogs and humans that is transmitted by tick bites. In people, Lyme is the most common tick-transmitted disease in the US, with over 25,000 cases in 2014.

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Identification of a Novel Juvenile Myoclonic Epilepsy Gene and Its Underlying Disease Mechanism

Epilepsy is the most common neurological disease in dogs and affects almost all breeds. Genetics is likely to play a major role in seizure risk, and gene discovery remains as an important goal to better understand the disease and its treatment.

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Investigating a Ketogenic Medium-Chain Triglyceride (MCT) Supplement for the Treatment of Drug-Resistant Canine Idiopathic Epilepsy and Its Behavioral Comorbidities

Canine epilepsy is a chronic neurological condition, often requiring lifelong medication with anti-epileptic drugs (AEDs). Despite appropriate treatment with available AEDs, seizure freedom may not always be achievable.

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