Grants

Lyme Disease in Dogs: Prevalence, Clinical Illness, and Prognosis

Lyme disease (or Borreliosis) is a bacterial disease of dogs and humans that is transmitted by tick bites. In people, Lyme is the most common tick-transmitted disease in the US, with over 25,000 cases in 2014.

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Identification of a Novel Juvenile Myoclonic Epilepsy Gene and Its Underlying Disease Mechanism

Epilepsy is the most common neurological disease in dogs and affects almost all breeds. Genetics is likely to play a major role in seizure risk, and gene discovery remains as an important goal to better understand the disease and its treatment.

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Investigating a Ketogenic Medium-Chain Triglyceride (MCT) Supplement for the Treatment of Drug-Resistant Canine Idiopathic Epilepsy and Its Behavioral Comorbidities

Canine epilepsy is a chronic neurological condition, often requiring lifelong medication with anti-epileptic drugs (AEDs). Despite appropriate treatment with available AEDs, seizure freedom may not always be achievable.

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Identification of Genetic Risk Factors for Canine Epilepsy

Epilepsy is one of the most common neurologic diseases of dogs and a top concern of dog breeders.  In spite of strong evidence that genetics is important in determining the risk of the common idiopathic epilepsy, numerous gene mapping studies have failed to identify a locus that accounts for that risk in either dogs or humans.

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Canine Epilepsy: Genetic Variants, Biomarkers, and New Therapies

Epilepsy is a significant seizure disorder affecting all dog breeds. It is the most common chronic nervous system disorder in dogs, with a prevalence of 0.5% – 5.7%, resulting in approximately 2 million affected dogs in the USA.

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Neurostimulation: A Groundbreaking New Treatment for Canine Epilepsy

Epilepsy is a debilitating condition that affects a large number of dogs, resulting in premature death and distress for their owners. For many dogs the underlying cause is unknown.

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Mapping of Genetic Risk Factors for Canine Hip Dysplasia

Canine hip dysplasia is a common developmental disorder of the hip joint that severely affects a dog’s quality of life. As the disease has several genetic risk elements and is influenced by environmental factors like diet and exercise, it is of paramount importance that genetic association studies are conducted using adequately-sized cohorts of genotyped diseased and healthy animals.

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Development of a Regenerative Medicine Technique to Treat Cartilage Disorders in Dogs

Osteochondrosis is a common and debilitating disease affecting large, athletic dogs. Osteochondrosis is caused by abnormal endochondral ossification, the process by which growth plate cartilage adjacent to joint surfaces transitions from cartilage to bone.

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Discovery of Biomarkers to Detect Lymphoma Risk, Classify For Treatment, and Predict Outcome in Golden Retrievers

Lymphoma strikes 1 in 8 Golden Retrievers, approximately one-third of the cases being B cell.  While T cell classifications currently inform therapy choices for dogs, B cell classifications have been investigated little in Golden Retrievers. 

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