Grants

Identification of Genetic Risk Factors for Canine Epilepsy

Epilepsy is one of the most common neurologic diseases of dogs and a top concern of dog breeders.  In spite of strong evidence that genetics is important in determining the risk of the common idiopathic epilepsy, numerous gene mapping studies have failed to identify a locus that accounts for that risk in either dogs or humans.

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Canine Epilepsy: Genetic Variants, Biomarkers, and New Therapies

Epilepsy is a significant seizure disorder affecting all dog breeds. It is the most common chronic nervous system disorder in dogs, with a prevalence of 0.5% – 5.7%, resulting in approximately 2 million affected dogs in the USA.

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Neurostimulation: A Groundbreaking New Treatment for Canine Epilepsy

Epilepsy is a debilitating condition that affects a large number of dogs, resulting in premature death and distress for their owners. For many dogs the underlying cause is unknown.

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Mapping of Genetic Risk Factors for Canine Hip Dysplasia

Canine hip dysplasia is a common developmental disorder of the hip joint that severely affects a dog’s quality of life. As the disease has several genetic risk elements and is influenced by environmental factors like diet and exercise, it is of paramount importance that genetic association studies are conducted using adequately-sized cohorts of genotyped diseased and healthy animals.

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Development of a Regenerative Medicine Technique to Treat Cartilage Disorders in Dogs

Osteochondrosis is a common and debilitating disease affecting large, athletic dogs. Osteochondrosis is caused by abnormal endochondral ossification, the process by which growth plate cartilage adjacent to joint surfaces transitions from cartilage to bone.

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Discovery of Biomarkers to Detect Lymphoma Risk, Classify For Treatment, and Predict Outcome in Golden Retrievers

Lymphoma strikes 1 in 8 Golden Retrievers, approximately one-third of the cases being B cell.  While T cell classifications currently inform therapy choices for dogs, B cell classifications have been investigated little in Golden Retrievers. 

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