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Single Nucleus RNA Sequencing of Canine Hemangiosarcoma – A Comparative Study of Splenic, Extra-Splenic, and Metastatic Tumor Profiling for Targeted Therapeutic Development

#03286 Grant Period: October 1, 2024 – September 30, 2026

Hemangiosarcoma is a cancer originating from the lining of blood vessels, predominantly affecting larger dogs. These dogs often present as an emergency because they have a bleeding mass in their abdomen. Unfortunately, this aggressive cancer spreads rapidly, and most affected dogs survive only 23 months after surgical removal of their bleeding tumor, with chemotherapy extending survival to 4-6 months.

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Towards Curative Outcomes in Canine Hemangiosarcoma

#02946 Grant Period: November 1, 2021 – October 31, 2026

Canine hemangiosarcoma is the most aggressive cancer seen in all dogs, but disproportionately affects older, large breed dogs. Despite aggressive treatment with surgery and chemotherapy, more than 50% of dogs die due to metastatic spread of their cancer within 6 months and no significant advancements in the treatment of hemangiosarcoma have occurred in over 30 years.

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